Alcohol, Chemistry and You
Case Study - Jolene, Alli and Warren
Dr. Matt Hermes

 

Smokey is a little guy with a handlebar moustache and a crooked back. He chooses the moustache to draw attention from his bald head. The crooked back chose him as result of being thrown from a bull when he was young and wild and in living in Wyoming. 

You can talk to him standing in the door of the ambulance in Glenwood Springs, CO, arms folded and a tired look in his eyes.

Jolene: "I get to know the alcoholics," he says.  "We're a young town and some of them get so bad, so young.  I take them to the hospital and I visit them there and they get to know me.  Some of them call me when they need help before they call the ambulance.  Take Jolene.  She couldn't stop drinking.  She worked at the community college here, in the administrative office.  She knew the kids and she drank with them.  Fifteen years of that and her body went. 

"I took her to the hospital one night when her roommate found her blacked out and bleeding at the bottom of her stairs.  She stopped drinking for a while and she told me she went to Alcoholics Anonymous.  But I noticed she began to get really puffy, not fat but puffy like she was retaining all kinds of fluid. She called me last November and she was drunk.  She was crying and she said she wanted to go to an AA meeting.  Would I take her?  Well I knew where they were so I dropped her off there.  An hour later a call came in from the church where the meeting was.  She had passed out and we took her to the hospital.  She never regained consciousness and in three days she was dead.  Doc Hammer, the emergency room guy said her whole system had shut down.  Her liver was shot and her whole system stopped working.  She was 36 years old." 
 
  

1. Review Effects of Alcohol on Organ Function:  
2. List the system failures caused by chronic over consumption of alcohol on the : a. Brain
b. Liver
c. Kidneys
d. Cardiovascular system
 3. Read the reference on cirrhosis of the liver and answer the following questions on the chemistry of cirrhosis: e. Vitamin E prevents the formation of active chemical species called free radicals. Alcoholic drinking inhibits the ability of Vitamin E to do its job.

Ethanol is oxidized to acetaldehyde in the liver, and then, without the inhibitions offered by Vitamin E, it is converted to damaging free radical. Write the chemical equations showing the oxidation of ethanol to acetaldehyde and the formation of a free radical from the acetaldehyde.

4. Liver transplants can restore critical functions lost through alcoholic drinking. f. But transplants pose an ethical dilemma. Should a transplant liver be given to a person who is still drinking?

Alli: "The thing about Allie was he always crashed the same way. Literally," Smokey says. " Allie is a plumber and when he isn’t drinking he is a sweet, happy guy. And then he starts drinking, and two things happen. He gets depressed and then he crashes his car.

"Last year he had a year or two without a drink and I saw him coming out of the liquor store with a paper bag under his arm. Uh, oh, I thought. He was doing plumbing in my house then and one day he disappeared for two hours. I went looking for him and he had crawled under the house, into my crawl space, and he was just lying there, his face into the ground. He was unable to move, to do his job, to call for help. And the next month he t-boned his car on route 40 – he pulled right through a red light. I was in the ambulance and when I got there, he was bad! Not hurt, but wild, biting, kicking and foul, foul language. He blew a 0.26 – up in the dangerous range and we had to put him in restraints in the hospital!"

Smokey said he has lost touch with Allie for now but found out he had been in the State Hospital in Pueblo for six months. And he had heard that Allie was now two years from a drink. What had happened, Smokey said, was that Allie had been taking a new medication, called Naltrexone that stops the desire, the craving to drink in many people, and he was taking his anti-depressants, too. And he was also going to AA.

Allie was in Arkansas now, he had met a woman in the hospital and he was living with her outside Ft. Smith.

1. Review Effects of Alcohol on Organ Function: a. Write a summary of how the brain develops a need for alcohol stimulation and how craving is developed when alcohol is withdrawn.
 2. Read the reference on Naltrexone and on the combined therapy that Dr. Volpicelli recommends. b. What methods have you seen used to help those you know with trouble with alcohol?
3. Now read the full medical summary of the drug's actions and side effects. c. Has this disclosure helped you make any decisions whether you would recommend Naltrexone?

Warren: "I never had Warren in my ambulance," Smokey said. "Oh yes I did. It was the time he had lost his driver’s license for his second DWI and he had to get to work. He was living with his mom way up on a hill over town and he drove down the hill on his bicycle, drunk. He crashed where you make the turn to the post office and lay there, bleeding and stunned. They patched him up. But he was a mess. I was over his mother’s house on the Fourth of July to see the fireworks and he was just one scab all over."

Smokey said right after that he drove Warren to Utah to make a court date, then dropped him off at a Rehab. Warren left there the next day, telling them he didn’t have a problem with alcohol, he was just having a string of bad luck. He was back in town within a week and got arrested breaking into the pool hall over by the trailer park. He was always playing pool there but he still forgot that the owner lived in the back room. The owner marched him out, hands behind his head and into the arms of a uniform.

"Warren’s in the county jail now, "Says Smokey. "I go over there one night a week to volunteer and he looks good. He says no more drinking for him, but he also says he can control it any time he wants. I don’t know about that. There’s a certain look in the eyes of a person that’s not done drinking yet. And I’m afraid Warren still has that look. He’ll be out around Thanksgiving and I hope he doesn’t use the holidays as an excuse to start drinking again".

1. How can you tell whether you or someone close to you has an alcohol problem?


CAGE Test:
A good first step is to answer the brief questionnaire below, developed by
Dr. John Ewing. (To help
remember these questions, note that the first letter of a key word in each question spells "CAGE.")

a. Have you ever felt you should Cut down on your drinking?
b. Have people Annoyed you by criticizing your drinking?
c. Have you ever felt bad or Guilty about your drinking?
d. Have you ever had a drink first thing in the morning to steady your nerves or to get rid of a hangover (Eye
opener)?

One "yes" answer suggests a possible alcohol problem. More than one "yes" answer means it is highly likely that a problem exists. If you think that you or someone you know might have an alcohol problem, it is important to see a doctor or other health provider right away. He or she can determine whether a drinking problem exists and, if so, suggest the best course of action.

a. Smokey suspects that like many alcoholics, Warren may still be in a state of denial about the full impact of his dependence and abuse of alcohol.

The biggest problem with alcohol is that it is so hard for the person affected to take the first step and seek help. But in fact, most who meet the CAGE criteria, do in fact, have a problem that may well get relentlessly worse!

Take the CAGE test with a classmate. Think about what the results might mean for you!


Note: Smokey is real although he no longer rides Colorado ambulances. He prefers golf in Nevada. Jolene, Alli and Warren are real, too, in a sense. Their names are changed but each is based on a young person from a small Colorado town. Jolene died in 2000 as described. Alli still drifts in and out of depression and sobriety and the real Warren is, in fact sober and was married in July 2001.
   


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©2003 Kennesaw State University
Principal Investigator Laurence Peterson
Project Director Matthew Hermes